In addition to that, I would also worry about interactions between issues. I tend to lean towards spreading out the issues over time to make the eventual diagnosis easier.

Occasionally we'll have a problem where we cannot deploy to production for several days (normally it's once a day). A massive inventory of ready-to-deploy features builds up. When we do finally deploy, this deluge of features and fixes creates new issues that force a rollback, delaying the deploy even longer...