he's not making a statement about brains, more the nature of reality. it's a perspective that's gaining traction lately with the dataist/reality-is-information line of reasoning.
ah he's distinguishing between ontology and epistemology ? He's saying there's only one reality but our instantaneous measurements of it (the given - what we perceive with our brains) form the illusion of time
the single vast space-time would already be locked in a state of maximal entropy, nothing moves, the illusion of time is just the universe recalling a memory.