Sure, always happy to help.

It’s possible to turn bluetooth on while in flight mode. People use bluetooth headphones a lot in flight. One of the premier use case of Bose’s noise cancelling bluetooth headphones is to use on planes. No announcement is made to ask people to not use bluetooth. No flight attendant asks people to not use bluetooth headphones. Planes are not crashing.

It’s probably safe to use bluetooth headphones on a plane.