You're a cardiology fellow, so you're likely much better versed in this than me, but take a look at the paper cited here:
Sure looks like they were doing multiple comparisons until they found a happenstance significant subgroup. : |
"Several studies have supported a potential link between irritability and statins, including a randomised controlled trial – the gold-standard of scientific research – that Golomb led, involving more than 1,000 people. It found that the drug increased aggression in post-menopausal women though, oddly, not in men."
They adjusted for multiple comparisons, and after that even the post menopausal group wasn't significant. The bit about how that doesn't matter because testosterone mechanisms and independent chance seems very hand-wavey to me.
(Moved my broader comment on this from a reply here to it's own reply to the thread.)
“Among (postmenopausal) women, a borderline aggression-increase on statins became significant with exclusion of one younger, surgically-menopausal woman (N=310) β=0.70(SE=0.34)P=0.039.”
Sure looks like they were doing multiple comparisons until they found a happenstance significant subgroup. : |
"Several studies have supported a potential link between irritability and statins, including a randomised controlled trial – the gold-standard of scientific research – that Golomb led, involving more than 1,000 people. It found that the drug increased aggression in post-menopausal women though, oddly, not in men."
https://journals.plos.org/plosone/article?id=10.1371/journal...
They adjusted for multiple comparisons, and after that even the post menopausal group wasn't significant. The bit about how that doesn't matter because testosterone mechanisms and independent chance seems very hand-wavey to me.
(Moved my broader comment on this from a reply here to it's own reply to the thread.)