One thing you forget to mention, but were kind of indirectly saying (I think), is the "reliability, consistency, convenience, and performance" leads directly to creativity in a way that in-the-box stuff can't replicate. Personally, I need to get to the sound I'm designing quickly for my creative flow to continue, if I fight the computer's UI (and let's face it, the vast majority of DAWs and plugins have terrible UIs) then it kills it for me. I end up self censoring (not even bothering to try) and the music that I end up making ends up more 'rigid'.
I think if you're the kind of person has infinite patience, then yeah sure, you could probably achieve similar results, but I think for many that's not going to work.
Another aspect is the true analogue modules, which software still struggles to emulate well. This matters for some modules/synths more than others, but there is a quality difference. Again, with time, one could make a digital synth/module sound good, but for me it's the same problem of killing the creative flow.
I think if you're the kind of person has infinite patience, then yeah sure, you could probably achieve similar results, but I think for many that's not going to work.
Another aspect is the true analogue modules, which software still struggles to emulate well. This matters for some modules/synths more than others, but there is a quality difference. Again, with time, one could make a digital synth/module sound good, but for me it's the same problem of killing the creative flow.