I used to be a humongous fan of 2D adventure games. Most notably the Space Quest series. If you've never played them start out with Space Quest 4 and then play SQ6. The audio dialog in the game is unrivaled humor. Full Throttle was also one of the mega-classics of 2D adventure games. I think the downfall of these games came when the studios tried to go the 3D route.
The story, characters, art direction, music and puzzles were brilliant. I'm pretty sure the interface could have been better, though. Steering Manny through the environments felt like driving a malfunctioning tank at times.