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There are supplements, backed by research, that practically remove all of the negative side effects of adderall. To start with, the sadness you felt on vyvanse sounds like dopamine depletion. You want to be taking l-tyrosine to make sure there’s plenty of fuel for the amphetamine to work with. ALCAR + ALA counteract the psychomotor agitation and tolerance formation. Magnesium + zinc help with muscle cramping. Selenium is neuroprotective. And of course you want to make sure you’re getting enough electrolytes (sodium + potassium) and balancing your intake, as a general rule for life, but especially if you take stimulants.

With the aforementioned supplement stack I’ve been able to go off doses as high as 60 mg of adderall per day without any significant withdrawal symptoms. It’s been a complete game changer in terms of making this medication a sustainable option for me. I will say as a caveat that things which reduce drug tolerance formation also typically attenuate some of the effects. In my case, ALCAR + ALA basically erase the potential for euphoria but don’t seem to diminish the mental benefits.



Dextromethorphan is the most potent anti-tolerance medication you can get your hands on, and it doesn't dampen any effects like ALCAR can.

I used to experiment heavily with all kinds of supplement routines and other nootropics when I had my Adderall Rx.

ALCAR works but like you mentioned, it does blunt things a bit.

https://clinicaltrials.gov/ct2/show/NCT03729128

https://link.springer.com/article/10.1007/s11373-006-9096-4

Dextromethorphan works for tolerance on things other than Amphetamine as well, but that's outside the scope of the conversation.

FWIW, the best I ever felt was on Adderall + 200mg l-Theanine + 10mg Noopept + 15mg Dextromethorphan.


Can you recommend any sources for the mentioned supplements and their interaction with amphetamines?


I’d try to retrace my path through the research for you but I’m on mobile for the rest of the day. I got the anecdotal recommendations from Reddit and then was able to confirm everything on google scholar. So just search for “amphetamine + supplement” on scholar and it should be easy to find the relevant papers. I will say that a lot of them were animal studies but I seem to recall at least a few human trials in the mix.


On magnesium. It’s been a huge help for migraines and muscle aches. Aside from zinc the others haven’t been on my radar.

Ordering the rest now.

My chief issue is nerve damage. Anything that helps them is a big win.




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