In general, DPH seems like a terrible anticholinergic and obsolete antihistamine with limited uses. My ex-stepfather abused it nightly as a "sleep aid," his personality altered, became very depressed, and I think entered a pre-dementia/Alzheimer's state sooner than he would've otherwise.
Probably not a good idea to experiment personally with GHB because it's Class I in the US and associated with date-rape, but it's worth considering in studies and research.
It does seem to be the case that disordered sleep is the keystone of depression; I can also confirm missing one dose of mirtazapine at night feels exactly like an alcohol-induced hangover in the morning. I suspect depression accumulates during sleep.
Interestingly, mirtazapine is a powerful H1 antihistamine that induces sleep at lower doses that are swamped by noradrenergic effects at higher doses. I would guess patients on mirtazapine have fewer incidents of seasonal allergies.
Probably not a good idea to experiment personally with GHB because it's Class I in the US and associated with date-rape, but it's worth considering in studies and research.
It does seem to be the case that disordered sleep is the keystone of depression; I can also confirm missing one dose of mirtazapine at night feels exactly like an alcohol-induced hangover in the morning. I suspect depression accumulates during sleep.
Interestingly, mirtazapine is a powerful H1 antihistamine that induces sleep at lower doses that are swamped by noradrenergic effects at higher doses. I would guess patients on mirtazapine have fewer incidents of seasonal allergies.