Yeh that makes sense actually. I guess the control methods would be different, but I can see on the LOVR docs that keyboard and mouse are also supported.
Maybe my concern with it comes with using 3D engines that can "also do 2D", but then when you try to do 2D with them, you find out its a bit of a hack job
You can trivially disable VR in LÖVR and use it for 3D.