Except when the API is overloaded, which is often. Then Twitter.com just spins for a long while and gives a message about trying again while failing to load your tweets at all.
I have twitter's new UI open in a tab all day long. I click the "X new tweets" button abou 20 times a day. I read tweets, checkout other twitterer's feeds, and it never ever slows down for me.
When I read about this guy seeing over a minute page loads, all I could think was, something is wrong with your computer or network dude.
Maybe your day does not line up with times Twitter has had capacity issues. Maybe it's maintenance during non-peak hours. I don't know, except that I've definitely seen Twitter's new UI time out as often as I saw the fail whale in the old UI.
I get that all the time but it seems to be a problem with Chrome. Some people say clearing the cache would fix it but that doesn't work for me. I have no such problems in Firefox though.