If you ever read these comics, I think you'd understand that it would be extremely odd to see these characters in an ad for e.g. coca cola or some such. Calvin and Hobbes have very well-defined characters that would seem very out of place in a profit-oriented environment.
I feel it could be the same for Mafalda, which I just realized I haven't seen outside of comics. Or maybe I'm too young?
The internet is tricky for these things though, if you search "calvin and hobbes mug" you'll definitely find a lot of them to buy, same as with Mafalda, so not sure how to validate this feeling.
Totally agreed. These are the counterexamples. I loved C&H and am glad that I don't have to deal with either of them trying to sell me toothpaste or car insurance. Super glad.