Scott McCloud of Zot fame was an early adopter of the web, I attended a talk from him where he was talking about how frustrated he was that the 3 panel format had persisted to the web, when there were so many ways to use space creatively.
He later adapted that talk for his "understanding comics" Ted talk. Worth a watch if you love the medium
I've got all his books and he's even linked to one of my comics in the past. http://egypt.urnash.com/rita/ if you're curious.
It's pretty cool on a decent-sized screen, it was designed around the size of the iPad I'd just gotten when I started it. Not so cool on a phone. Try it on both and you'll see what I mean.
He later adapted that talk for his "understanding comics" Ted talk. Worth a watch if you love the medium