The benefit is that it's extremely streamlined and simplified to suit the specific type of assets it is designed to create. It is designed for hobbyists- people creating assets for things like Minecraft and Roblox, or indie games- not for people who already know how to use something like Blender.
If you already know how to use Blender then, yes, do that.
Even if you're familiar with Blender, there can be value in having a more focused tool. I've tried using it for low-poly 3D modelling before and it's annoying having so much of the interface dedicated to functionality I can't use.
Using a limited palette has been a point of friction in Blender, too. You can't update the palette from within Blender, and you need to use tiny UV coordinates.
It gives a much better quick impression of what this tool is like.