Other than questionable ethics, it can lead to immediate termination.

But as always, there's lying and "lying". Saying you quit when you were laid off, I would consider lying. Telling you needed new challenges when in fact your boss was so toxic you wanted to quit the universe, not lying.

In the end, a job interview is a courting dance and you'd want to put your colorful feathers on, but at least they should reflect your reality.