You’ve changed the context from medical use to recreational by druggies with irresponsibly high doses feeling like suicide afterwards. I have a sense of the point you’re attempting but it’s murky and isn’t a useful response.

But medics who has that information does not use HN unlike the druggies. Druggies report that effect of mdma might be a long-term but this is not a prolonged effect of the substance, this is just positive outcomes from a good social interaction session which may happen with significantly more probability if on mdma. For example: had a uncomfortable but long-term useful talk, could behave openly on some party after a long time without that experience and gained new best-friend for tens of years, danced better on some dance competition which resulted in participation of higher-level competitions, etc. Prolonged anti-depression effect is a killer feature of shrooms.