It comes with a bunch of "fixes" (AKA DLL straight from Windows) you can optionally download if the app doesn't start. I actually managed to run Cinema 4D R21 with Bottles quite painlessly. I had harder time installing flatpak (to install bottles) on a Porteus distrib than running Cinema 4D.

I am wondering about that as well. I can (and do) use different WINEPREFIXes for different programs with regular Wine too.

I assume this just takes the setup of those WINEPREFIXes out of the equation? Like having pre-defined configs/winetricks/tweaks/DllOverrides/whatever for certain games? Maybe with a couple of patches to Wine that are not yet upstream?