And if you're USAF, you practically strip the aircraft to its frame every few years, inspect, repair, and reassemble it. The dangers are known and the process around it is there to deal with those dangers.
Most aircraft fleets operated by people who care will do something similar but perhaps not as extreme. In fairness to them they don't expect to fly the plane as long as USAF does (70+ years for the B-52, 50+ for many fighters).
