As a DIY option, there are definitely ways you could add MFA-like security with a simple switch/relay (attached to said authentication factor) in most ignition systems.
However, that wouldn't help with the "desyncing" or unlocking aspects of this attack.
I had a used VW gti (late last century) with an imobilizer. It let the engine crank but wouldn’t start. It also locked the hood from opening, leading to some panic when first getting the car and forgetting it had this feature.
However, that wouldn't help with the "desyncing" or unlocking aspects of this attack.