So knowledge becomes meta stable. There was an AIDS drug in the 90’s that we stopped being able to make. IIRC Apparently there were two different crystal/folding structures for the compound and the desired one was not the lowest energy. After years of production, the wrong version was produced and they could no longer make the correct version do to contamination. And every facility that tried to study it, wound up no longer being able to make the correct version. It was like a real life ice-IX situation. Scary that changing weights or model parameters could lead to the same thing happening with knowledge.