Of the all the radioactive elements in a nuclear reactor, uranium is one of the least dangerous (is very weakly radioactive, but it's toxic, it's a heavy metal). It's all the radioactive fission products (many have short half-life and in process of decay produces lot of ionizing radiation) and trans-uranic elements (because they have very long half-life and produce a bit small bits of ionizing radiation for very long time).
One possible of measure of danger is median lethal dose LD50:
Uranium LD50 in mice 114 mg/kg (about the same as Cocaine LD50 96 mg/kg)
There are places underground with high concentration of uranium, they are called uranium ore and sometimes they are mined for uranium.
"The deposit is located at depth of 450 m (1,480 ft), surrounded by and isolated within a layer of water-impermeable illite-chlorite clay, within the Athabasca Sandstone formation. Its age is estimated to be 1.3 billion years. Due to natural containment and lack of any traces of radioactive elements on the surface, the deposit is used as an example of an effective natural deep geological repository."
On the upside, the half life of those byproducts is measured in days to decades (15 years for Pu-241, 88 for Pu-238, 30 for Cs-137 and 139 days for Po-210).
A spend nuclear fuel rod, freshly taken out of nuclear reactor, will kill you in minutes, if stand near it without any shielding. Therefor manipulation with spend nuclear fuel is done remotely under water. Few meters of water are excellent radiation shield.
With each year radioactive products decay into stable elements.
After about 400 years in storage, the most radioactive elements decay away and the dominant part radiotoxicity of spend nuclear fuel is now Plutonium. From the point of toxicity, you could now handle the spend nuclear fuel as other industrial toxic waste - you have to breathe in, or ingest the spend nuclear fuel to be dangerous.
On the other hand, from the geopolitical point of view, spend nuclear fuel is dangerous from many thousands of years (in contrast to other industrial toxic waste), because for many thousands of years Plutonium can be used make a nuclear weapons. This is the real reason why spend nuclear fuel gets so much attention.
One possible of measure of danger is median lethal dose LD50:
Uranium LD50 in mice 114 mg/kg (about the same as Cocaine LD50 96 mg/kg)
Plutonium LD50 in dog 320 μg/kg
Caesium-137 LD50 245 μg/kg
Polonium-210 LD50 10 ng/kg (estimated)
https://en.wikipedia.org/wiki/Median_lethal_dose
There are places underground with high concentration of uranium, they are called uranium ore and sometimes they are mined for uranium.
"The deposit is located at depth of 450 m (1,480 ft), surrounded by and isolated within a layer of water-impermeable illite-chlorite clay, within the Athabasca Sandstone formation. Its age is estimated to be 1.3 billion years. Due to natural containment and lack of any traces of radioactive elements on the surface, the deposit is used as an example of an effective natural deep geological repository."
https://en.wikipedia.org/wiki/Cigar_Lake_mine