Some time after the Thunderbolt 3 MacBooks were released I had to get data off of a FireWire 400 drive. Thunderbolt 3 to Thunderbolt 2, Thunderbolt 2 to FireWire 800, FireWire 800 to FireWire 400. Everything mounted up just fine.

That's pretty impressive. The closest to that I personally dealt with was back in the days of Mac Quadras and the ADB port where software was protected with dongles that would daisy chain via ADB.

In audio connectors, I've had some pretty crazy builds getting from various formats when the exact right thing isn't available but a giant milk crate of random cables was on hand.