It makes efforts to be kernel-version-agnostic; you should be able to use most kernels from most major distros. So yes, if you have a package that requires some special kernel you can probably just use that kernel. However, you will have to reboot to switch kernels like most distros - if you have two packages that each require mutually-exclusive kernel features, you can't use them both at the same time.

For example, the Fedora kernel has special patches for systemtap. You should be able to just boot into the Fedora kernel to utilize systemtap from a fedora userland package, but still get all your other packages from other distros, if you'd like.