Sucrose can be regulated by your body with Sucrase, whereas HFCS cannot. Maybe that's part of the reason why so many Americans are overweight? Hard to escape HFCS in the average diet. Reference:
http://en.wikipedia.org/wiki/High-fructose_corn_syrup#Cane_a...
Yeah, but if you consume enough sucrose and you don't cleave it, you'll get the equivalent of lactose intolerance (lactose is a disaccharide of glucose and galactose instead of fructose).