There's some really exciting research going on around ageing (and cancer as they are quite related) recently. I'm someone very far outside the field, but as far as I can tell we're starting to understand cancer (and ageing) on a much deeper molecular machinery kind of level.
Combined with epigenetics it really does look quite doable to extend lifespans of humans as well. I mean there have been techniques known for millennia - fasting, exercise, saunas etc.
What's changing now is that we're starting to understand _how_ those things are actually working under the hood, not just spraying chemicals and hoping something changes.
Great read. The combination of metformin, revaratrol and NMN is quite something. Add fasting and an intense workouts and it’s amazing how much you can impact your wellness.
I recently unretired from the over 40 hockey league i’ve played in the past 8 years and rejoined the top A league playing against 20 year olds... anecdotal sure... but then again so are those sets of 30-40 pull-ups I do in my workout multiple times a week... incidentally in my 30s I could only do 15 pull-ups... been steadily increasing the last few years much to the surprise of my 20 year old teammates I workout with. I’m currently 52 and look mid 30s and have taken supplements for nearly 10 years to affect aging.
> I’m currently 52 and look mid 30s and have taken supplements for nearly 10 years to affect aging.
Might want some anonymous feedback on how old you really look before you use this tagline in the wild. ;)
It's always a bit awkward when someone tells you how many 15+ years younger they [think they] look and you're stuck between "should I tell them?" and "smile and nod." I always presume they keep getting older but forget to update the story. Soon they're 60 years old and still refer to themselves as baby-faced, their intramural flag-football nickname back in university.
1 gram of NMN, metformin and resveratrol. Beyond that I take other things including carbon 60. Those are the most exotic items; the rest are your usual items such as fish-oil, krill oil, multi-vitiman most of which I tuned from my Inside-Tracker.com blood results.
I also have the right genetics; aka longevity gene(s), Ashkenazi Jew markers, etc and my farther is in his upper 80's; his mother lived to 98.
I don't want to claim that it's any one thing. I'm sure it's everything. The Tabata style sprinting 2-3 days a week, the hour+ workouts minimum of 5 days a week, the 16/8 fasting, the hockey/cryotherapy-like effects of being cold and working out/aerobic exhaustion of being on the ice or skating outside etc. And of course diet... I eat much much less than most people I know (big fan of Paleo menu by Green-Chef).
The way I see it is there are studies around NMN, metformin and resveratrol right now; let's say in 10 years they all prove they slow aging/extend life... to me it's worth the cost to take these now and bet on a positive outcome. If some of these studies don't pan out, so it goes, but so far it seems like it's working out pretty well if my increasingly annoyed friends are any indication.
I do all of those things, but I am finding the NMN to be quite costly. I take almost the same amount as Dr. Sinclair, which means going through a bottle of pills every three to five days. I really hope someone makes a less expensive version soon. I do feel the difference and can probably attribute it to higher ATP production. I have no idea if it's helping my cardio vascular system.
You'll notice if you stop; that's what happened to me when my NMN went on back-order and stopped for 8 days.
Like metformin NMN doesn't produce any significant immediate noticeable effect like Alpha-GPC for example; it's more like working out - overtime the long-term effects are significant. At least that's the hope.
I buy my NMN in a month supply at a time (150 a month).
I second that. I have to spend a lot to get 800mg/day. That's why I would love to see more companies make it and the price come down. I fully understand the molecule is a little more complex than its precursor, but maybe if more people made it, then the price would come down? /shrug
Does your father looks a lot younger too? My father is in his mid 50s and he looks 40. I am in my mid 30s and I look younger too. This is genetics obviously. I am also doing fasting 16/8 and eat less than most people.
It's possible that those supplements have 0 effects and it's all just genetics.
> Not really but he smoked for 40 years before quitting around age 55.
My father smoked for around 30 years, I've smoked for around 16 years.
> Or it’s possible the preliminary results are correct.
Sure, it's a possibility too, I would like to see more long term studies tough, with enough participants to statistically exclude all environmental noise.
For now we can be sure of one thing, genetics is the main factor in how we age.
I've seen some articles suggesting that berberine (plus sylamarin) may be superior to metformin with fewer side effects (plus it's cheaper and doesn't require a prescription).
What's changing now is that we're starting to understand _how_ those things are actually working under the hood, not just spraying chemicals and hoping something changes.
At least that's what I've gathered reading through https://lifespanbook.com/faq/